What is it and what does it include?
Motivated by suspected roles for epigenetic modifications in AD, investigators performed a genome-wide screen of DNA methylation on bulk tissue samples from the superior temporal gyrus (STG) of 34 patients with AD and 34 controls, a brain region recently demonstrated to be a site of significant AD-associated gene dysregulation. Investigators paired a sliding window approach with linear models that account for age, gender, ethnicity, and estimated cellular proportions (neuronal vs. glial), to characterize AD-associated differentially methylated regions. Whole DNA was extracted from STG tissue dissections collected from deceased individuals with and without AD.
The goal of investigators was to identify differentially methylated regions harboring multiple statistically significant CpGs exhibiting concordant disease-associated changes in methylation.
How can I use this dataset to advance my research?
This dataset is ideal if:
- you’re studying differences in methylation in the superior temporal gyrus (STG) of patients with and without late‑onset AD based on epigenome‑wide DNA methylation data.
Has this dataset helped researchers understand Alzheimer’s and other dementias better?
Of course!
- AD & DNA methylation:
In 2017, investigators aimed to identify differential methylation in the superior temporal gyrus (STG) of patients with late‑onset AD based on epigenome‑wide DNA methylation data by bioinformatics analysis. Results showed that AD subjects demonstrated distinctive DNA methylation patterns when compared with the controls. Hypermethylation was mainly detected for genes regulating the cell cycle progression, whereas hypomethylation was observed in genes involved in transcription factor binding. The present study demonstrated widespread and distinctive DNA methylation alterations in late‑onset AD. Identification of AD‑associated epigenetic biomarkers may allow for the development of novel diagnostic and therapeutic targets. October 2017 – DOI: https://www.spandidos-publications.com/10.3892/etm.2017.5394
- AD & Epigenome-wide association study (EWAS):
In 2016, researchers characterized changes in DNA methylation in the superior temporal gyrus of patients with Alzheimer’s disease, highlighting novel loci that facilitate better characterization of pathways and mechanisms underlying Alzheimer’s disease pathogenesis, and improve our understanding of epigenetic signatures that may contribute to the development of disease. January 2016 – DOI: 10.1186/s13073-015-0258-8